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Genetically predicted effects of DHA and EPA on cognitive performance: evidence from two-sample Mendelian randomization
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| dc.contributor.author | SIMINIUC, Rodica | |
| dc.contributor.author | ȚURCANU, Dinu | |
| dc.date.accessioned | 2026-05-19T08:00:52Z | |
| dc.date.available | 2026-05-19T08:00:52Z | |
| dc.date.issued | 2026 | |
| dc.identifier.citation | SIMINIUC, Rodica and Dinu ȚURCANU. Genetically predicted effects of DHA and EPA on cognitive performance: evidence from two-sample Mendelian randomization. In: Biotehnologiile şi dezvoltarea durabilă = Biotechnologies and Sustainable Development: Simpozion Ştiinţific Naţional cu Participare Internaţională, Chişinău, 12 mai 2026. Universitatea Tehnică a Moldovei, Institutul de Microbiologie şi Biotehnologie. Chişinău, 2026, p. 131. ISBN 978-9975-3711-6-2, ISBN 978-9975-3711-7-9 (PDF). | en_US |
| dc.identifier.isbn | 978-9975-3711-6-2 | |
| dc.identifier.isbn | 978-9975-3711-7-9 | |
| dc.identifier.uri | https://doi.org/10.52757/bsd26.64 | |
| dc.identifier.uri | https://repository.utm.md/handle/5014/36235 | |
| dc.description | This research was funded by the National Agency for Research and Development (NARD), grant no. 25.00208.7007.05/PD “Nutritional Resilience of the National Army Personnel: Integrating Smart Systems for Food Management and Deficiency Prevention”, Technical University of Moldova. | en_US |
| dc.description.abstract | Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are biochemically distinct long-chain omega-3 polyunsaturated fatty acids with different brain distributions and metabolic roles. Despite their biological specificity, most intervention trials administer combined supplements, precluding fatty acid-specific causal conclusions. Whether individual circulating DHA and EPA levels exert independent effects on cognitive function remains unresolved. Aim of the study: To estimate and formally compare the genetically predicted causal effects of circulating DHA and EPA on reaction time and general cognitive performance using a twosample Mendelian randomization (MR) framework, with explicit assessment of FADS-cluster pleiotropy. | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Technical University of Moldova | en_US |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
| dc.subject | mendelian randomization | en_US |
| dc.subject | cognitive performance | en_US |
| dc.subject | pleiotropy | en_US |
| dc.subject | causal inference | en_US |
| dc.title | Genetically predicted effects of DHA and EPA on cognitive performance: evidence from two-sample Mendelian randomization | en_US |
| dc.type | Article | en_US |
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2026
Chişinău, 12 mai
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 United States