The grapes and wine sector in the Republic of Moldova is a strategic one for the national economy. During the 2020- 2021 year, a study was conducted on the factors influencing the development of enterprises in the grapes and wine sector in the Republic of Moldova. The research was carried out within the project: "Impact of macromedia and geographical factors on bankruptcy and business performance of economic entities in the agri-food sector in the Republic of Moldova", project code 20.80009.0807.26, according to contract between SAUM and NARD. The study was conducted by interviewing companies. As a result of the study it was established: economic factors/risks obtained an average rating of 4.3 points on the scale of 5 pt.; technical and technological factors/risks obtained an average rating of 4.2 points on the scale of 5 pt.; ecological factors/risks obtained an average rating of 4.2 points on the scale of 5 pt.; legislative-legal factors/risks obtained an average rating of 4.1 points on the scale of 5 pt.; information factors / risks obtained an average rating of 4.2 points on the scale of 5 pt.; moral factors/risks obtained an average rating of 4.3 points on the scale of 5 pt.