https://repository.utm.md/handle/5014/15 2026-10-29T02:33:41Z 2026-10-29T02:33:41Z IAPĂSCURTĂ, Victor https://repository.utm.md/handle/5014/37666 2026-10-28T17:28:11Z 2026-01-01T00:00:00Z

Intelligent methods and software algorithms for intensive care. A complexity science approach IAPĂSCURTĂ, Victor The aim of the study. To develop new intelligent methods, algorithms and software applications for intensive care medicine based on complexity science to improve early diagnosis, prediction and management of severe conditions such as sepsis and epileptic seizures. Scientific novelty and originality. The thesis introduces a novel integration of complexity science into intensive care to exploit nonlinearity and emergence to fill diagnostic gaps. It is the first to use KCC (block decomposition) as preprocessing method for biomedical signals to detect patterns in non-stationary data. Hybrid modelling framework combining agent-based and system dynamics approach for multiscale simulations such as fetal oxygen delivery is introduced. Large language models with retrieval augmented generation and multi-agent systems for sepsis management are new approaches to real-time clinical decision making which set this work apart from traditional reductionist methods. Applicative value of the work. The developed tools provide practical solutions for early sepsis prediction and management and EEG seizure forecasting; enhance clinical decision making and personalized care. These applications are scalable for resource poor settings (Moldova) ICU triage, intervention planning and medical education through simulations.; Scopul studiului: Dezvoltarea unor noi metode inteligente, algoritmi și aplicații software pentru medicina de terapie intensivă, bazate pe știința complexității, în vederea îmbunătățirii diagnosticului precoce, a predicției și a gestionării afecțiunilor grave, precum sepsisul și crizele epileptice. Noutate științifică și originalitate. Teza introduce o integrare nouă a științei complexității cu terapia intensivă, valorificând neliniaritatea și emergența pentru a aborda lacunele de diagnostic. Este pionieră în utilizarea complexității Kolmogorov-Chaitin (KCC) prin descompunerea în blocuri pentru preprocesarea semnalelor biomedicale, îmbunătățind detectarea tiparelor în datele nestaționare. Cadrul de modelare hibridă, care combină abordări bazate pe agenți și dinamica sistemului pentru simulări, cum ar fi livrarea oxigenului fetal, este inovator. În plus, aplicarea modelelor de limbaj mari cu generare augmentată prin recuperare și sisteme multi-agent pentru gestionarea sepsisului reprezintă o abordare de ultimă generație a deciziilor clinice în timp real, distingând această lucrare de metodele reducționiste tradiționale. Valoarea aplicativă a lucrării. Instrumentele dezvoltate oferă soluții practice pentru predicția și gestionarea timpurie a sepsisului și prognoza convulsiilor bazată pe EEG, îmbunătățind luarea deciziilor clinice și îngrijirea personalizată. Aceste aplicații sunt scalabile pentru medii cu resurse limitate, cum ar fi Moldova, sprijinind triajul critic, planificarea intervențiilor și educația medicală prin simulări interactive. Fişierele ataşate: Teza de doctor habilitat & Rezumatul tezei de doctor. (Ro, En)

2026-01-01T00:00:00Z GADIBADI, Mihail ŢIŢEI, Victor ABABII, Alexei DOROFTEI, Veaceslav DARADUDA, Nicolae CÎRLIG, Natalia MELNIC, Victor https://repository.utm.md/handle/5014/37647 2026-10-28T12:04:42Z 2025-01-01T00:00:00Z

The melliferous potential and prospect of valorization of waste biomass of Coriandrum sativum, Salvia hispanica and Lavandula angustifolia for renewable energy GADIBADI, Mihail; ŢIŢEI, Victor; ABABII, Alexei; DOROFTEI, Veaceslav; DARADUDA, Nicolae; CÎRLIG, Natalia; MELNIC, Victor We investigated some biological peculiarities of Coriandrum sativum, Salvia hispanica and Lavandula angustifolia. It was established the studied plant species is characterized by an extended flowering period, providing food for bees from June to mid-August, with a honey potential of 60-330 kg/ha. The analysis of lignocellulose composition of collected waste biomass - dry stalks suggested that dry matter contained 357-504 g/kg cellulose, 197-248 g/kg hemicellulose, 72-135 g/kg acid detergent lignin and estimated theoretical ethanol yield from cell wall carbohydrates varied from 398 to 533 L/t. The physical and mechanical properties of dry stalks biomass from studied plant species was 3.36-4.48% ash, 73.17-79.39% volatile matter, 17.19-19.83 MJ/kg HHV, 15.86-18.46 MJ/kg LHV and can serve as feedstock for production solid densified fuel-pellets for renewable energy production.

2025-01-01T00:00:00Z COSTIN, Mircea NENCIU, Florin IONESCU, Alexandru SERBANCEA, Floarea SERBANCEA, Cristian POPA, Lorena-Diana CEREMPEI, Valerian https://repository.utm.md/handle/5014/37646 2026-10-28T11:14:17Z 2025-01-01T00:00:00Z

Modern pea sowing technologies: efficiency, precision, and sustainability in contemporary agriculture COSTIN, Mircea; NENCIU, Florin; IONESCU, Alexandru; SERBANCEA, Floarea; SERBANCEA, Cristian; POPA, Lorena-Diana; CEREMPEI, Valerian The protein content and quality of pea seeds are strongly influenced by cultivation practices and processing methods. Soil fertility, stress conditions, and harvest timing affect protein synthesis and amino acid profiles. Post-harvest treatments can enhance or degrade protein digestibility and nutritional value. Optimized agronomic and processing strategies are essential to ensure high-quality pea protein for human consumption. Pea sowing represents a crucial stage in the agricultural process, and the use of modern sowing technologies has brought significant improvements in the efficiency and sustainability of this process. Seeders, equipped with advanced depth and seed distribution control systems, enable uniform and efficient sowing, reducing resource waste. These modern technologies not only support more efficient resource management but also contribute to environmental protection by reducing the need for chemical treatments and improving soil structure. Additionally, the sowing process helps combat pests and diseases by ensuring even plant distribution, making them more resilient. Although implementing these technologies may involve high initial costs, the long-term economic and ecological benefits make them a valuable investment in agriculture. This chapter explores the impact of modern seeders on contemporary agriculture, highlighting the advantages and challenges associated with their use.

2025-01-01T00:00:00Z MELNIC, Rodica https://repository.utm.md/handle/5014/37645 2026-10-28T11:00:28Z 2026-01-01T00:00:00Z

Influence of tillage on cellulolytic activity in various agroecosystems MELNIC, Rodica The soil also represents a habitat for various organisms, which have a determining role in its functioning and evolution, in this way the soil is defined as an active biological system, with multiple functions, being indispensable for maintaining life and ecological balance. Due to its heterogeneous structure and the variability of physicochemical conditions, the soil shelters complex communities characterized by significant taxonomic and functional diversity. Soil microorganisms are an essential component of pedological and geoecological systems, playing a fundamental role in maintaining fertility, ecosystem functionality and environmental stability. They include bacteria, fungi, actinomycetes, algae and protozoa, which actively participate in biochemical processes in the soil. The density, diversity, and composition of soil microbiota depend on a set of factors: depth (determining oxygen penetration); soil structure; mineral composition; amount of organic matter (available food), temperature, moisture, and vegetation (involved in complex interactions with local microbiota). The lucerne variant indicates high cellulolytic activity, where litter decomposition, expressed as % of initial mass, amounted to 82.4% for the May-June period. Cellulolytic activity shows lower values for the June-July period compared to May-June, the reason being higher temperatures of 25-30 ºC and lower precipitation compared to May- June. They ensure nutrient recycling, maintain fertility and contribute to environmental stability. In the context of sustainable agriculture and environmental protection, the conservation of microbial biodiversity is a strategic priority.

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