SECTION OF BIOMEDICAL ENGINEERING https://repository.utm.md/handle/5014/27901 2026-04-12T03:42:40Z 2026-04-12T03:42:40Z BAS, Albert MUNTEANU, Viorel https://repository.utm.md/handle/5014/28097 2024-10-16T11:19:04Z 2024-01-01T00:00:00Z

A comprehensive assessment of sequence read archive metadata completeness BAS, Albert; MUNTEANU, Viorel Recent advances in high-throughput sequencing technologies have enabled the collection and sharing of a vast amount of omics data, along with its associated metadata. Enhancing the availability of this metadata is crucial to ensure the reusability and reproducibility of raw data, as well as for facilitating novel biomedical discoveries through efficient data reuse. In this study, we performed a comprehensive assessment of metadata completeness by analyzing over 26,000,000 experiments shared in the Sequence Read Archive (SRA) from 2008 to 2023. Our results show that the countries of Central Europe, the USA and China show dominance in generating sequencing data, corresponding to 45%, 16% and correspondingly 8% of total data in the SRA repository, the most frequently used platform is ILLUMINA (90%). Identified that some of the metadata contains inconsistencies in completeness: the absence of temporary identifiers (5.2%), the lack of assigned TaxonomyID (5%), and the absence of library strategy (8%). Our results highlight the urgent need for improved metadata sharing practices and the standardization of reporting.

2024-01-01T00:00:00Z GALATONOVA, Tatiana https://repository.utm.md/handle/5014/28096 2024-10-16T11:12:19Z 2024-01-01T00:00:00Z

Fabrication of ZnO nanofibers using electrospinning method GALATONOVA, Tatiana Zinc oxide (ZnO) nanofibers have attracted significant attention due to their unique properties and diverse applications in fields such as electronics, photonics, and sensing. Fabrication parameters play a crucial role in determining the morphology, structure, and properties of ZnO nanofibers synthesized via the electrospinning method. This mini-review systematically discusses the impact of critical parameters on the electrospinning process and the resulting characteristics of ZnO nanofibers. Parameters such as polymer concentration, solvent selection, applied voltage, spinning distance, and post-processing conditions are examined in detail. Furthermore, the influence of these parameters on the morphology, diameter distribution, crystallinity, and functional properties of ZnO nanofibers is elucidated. Strategies for optimizing these parameters to achieve desired morphologies and properties are also discussed. Understanding the interplay between fabrication parameters and ZnO nanofiber characteristics is essential for tailoring these materials to specific applications and advancing their technological relevance. This review provides valuable insights into the fabrication of ZnO nanofibers via electrospinning, guiding researchers and engineers toward effective synthesis strategies and future developments in this exciting field.

2024-01-01T00:00:00Z GORDEEV, Alexandr https://repository.utm.md/handle/5014/28092 2024-10-16T10:31:04Z 2024-01-01T00:00:00Z

Portable non-invasive device for lactate threshold determination GORDEEV, Alexandr Lactate is an important metabolic product that provides an opportunity for analysing a person's physical condition. This paper will focus on the phenomenon of anaerobic metabolic threshold. Receiving an accurate value of this parameter allows designing a precise training plan that corresponds to any goals, from prevention of cardiovascular diseases to achieving high performance in sports disciplines. There are different ways to find out lactate threshold but all of them either handy but not rigour or explicit but invasive. Therefore, this piece will offer options on how to create a minimally sized non-invasive device which allows to integrate a strict low cost, recyclable and convenient for use in any context lactate threshold measurement technology in sports centres and in the lives of people interested in their health and outcomes.

2024-01-01T00:00:00Z MACAROV, Alexandru https://repository.utm.md/handle/5014/28091 2024-10-16T10:21:19Z 2024-01-01T00:00:00Z

Pacemaker simulator MACAROV, Alexandru Un circuit stimulator cardiac a fost creat utilizând diverse componente electronice disponibile comercial, iar microcontrolerul ATmega328 a servit ca nucleu al întregului sistem. Circuitele stimulatorului sunt clasificate drept oscilatoare de relaxare, generând ieșiri repetitive nesinusoidale și fiind monitorizate printr-un buclaj de feedback. Pentru monitorizarea eficientă a activității electrice a inimii, s-a utilizat un senzor AD8232, care acționează ca un amplificator operațional, furnizând semnale clare și având capacitatea de a conecta semnale suplimentare pentru brațe și picioare. Controlul stimulatorului cardiac și interfața cu AD8232 au fost realizate folosind Arduino Uno, oferind un mediu de programare convenabil în limbajul C++. Asamblarea sistemului a fost realizată pe un breadboard, iar rezultatele testelor au fost vizualizate în Serial Plotter. În plus, pentru utilizarea ulterioară a sistemului în experimente, a fost proiectată o placă de instruire dedicată.

2024-01-01T00:00:00Z